Regulation of respiratory CD8+ T cell immunity by suppressive monocyte-like dendritic cells

Regulation of T Cell Immunity by Dendritic Cells

membrane rafts containing kinases and adapters to the Immune responses are initiated in the T cell areas of synapse and amplifies up to 100-fold the signaling prosecondary lymphoid organs, where naı̈ve T lymphocytes cess initiated by the TCRs. Thus, in the absence of encounter dendritic cells (DCs) that present antigens costimulation, naive T cells can be activated only by taken up in peripheral...

Semimature Dendritic Cells Tolerance and CD8 T Cell Immunity by Simultaneous Induction of CD4 T Cell

Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells.

Previous studies suggested that depending on their maturation state, dendritic cells (DC) could either induce T cell tolerance (immature and semimature DC) or T cell activation (mature DC). Pretreatment of C57BL/6 mice with encephalitogenic myelin oligodendrocyte glycoprotein (MOG)(35-55) peptide-loaded semimature DC protected from MOG-induced autoimmune encephalomyelitis. This protection was m...

Regulation of immunity to respiratory syncytial virus by dendritic cells, toll-like receptors, and notch.

The activation and maintenance of pulmonary viral disease is regulated at multiple levels and determined by the early innate response to the pathogenic stimuli. Subsequent activation events that rely directly and indirectly on the virus itself can alter the development and severity of the ensuing immunopathologic responses. In the present review we outline several interconnected mechanisms that...

Resident CD8+ and Migratory CD103+ Dendritic Cells Control CD8 T Cell Immunity during Acute Influenza Infection

The identification of the specific DC subsets providing a critical role in presenting influenza antigens to naïve T cell precursors remains contentious and under considerable debate. Here we show that CD8(+) T lymphocyte (TCD8+) responses are severely hampered in C57BL/6 mice deficient in the transcription factor Batf3 after intranasal challenge with influenza A virus (IAV). This transcription ...